Kind neighbours Lin and Pete Howarth have been putting on huge displays outside their home each year to help Frankie Ross, 14, whose physical and mental development is affected by the condition.
The money raised will go to two charities, Rett UK, which supports families, and Reverse Rett, which is researching to find a cure.
Lin, of Pitstone, said: “Frankie came nice and early and her face was a picture - she loved the whole thing. We had a wonderful turnout and we have been blown away by people’s generosity. The children loved the Zoomania mascot and all the balloons.
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“Wrightway Structural Steels in Wycombe matched our cash donations bringing our total to £1050.”
