People from the Bedford area were among 586 who were arrested as part of a clampdown on drugs gangs.
500 men and 86 women were arrested in raids which primarily centred on Norfolk, Suffolk, Cheshire, Bedfordshire, from May 13-20.
Police forces, led by the National County Lines Coordination Centre, also seized £176,780-worth of cocaine, crack worth £36,550, and heroin with a street value of £17,950.
And officers recovered £312,649 in cash, plus 46 weapons including guns, swords, machetes, an axe, knives, samurai swords, and a crossbow.
519 vulnerable adults and 364 children in need of support were helped, while 30 people were identified as potential victims of slavery or human trafficking.