The A5 has been closed both ways from Hockliffe to Chalk Hill following a collision between a lorry and a car at around 4pm today (Monday).
Bedfordshire Police and East of England Ambulance Service are in attendance. National Highways has traffic officers and service providers deployed to assist.
Police are urging motorists to avoid the area and diversions have been set up.
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The road is estimated to remain closed throughout the afternoon.